NK cell function was assessed using a 14-color flow cytometry panel, as previously described23, to identify changes in bulk NK cell receptor expression and function of NK cells … See more In an effort to define unique and common signatures of NK cell activity that was not detected at the protein level, due the constraints of flow … See more Due to the heterogeneous nature of NK cells, we further interrogated whether the gene expression patterns of NK cells are representative of the entire CD56dimCD16dim/neg … See more To examine biological pathways these differentially expressed transcripts are involved in, we next performed a Gene Set Enrichment Analysis … See more Utilizing data from the whole-transcriptome analysis of CD56dimCD16dim/neg NK cells in healthy donors we developed a panel of 96 genes within the … See more WebApr 15, 2024 · The transcription factor IRF4 controls activation and differentiation of CD8 + T cells; however, its role in memory T cells is unclear. Here, we use a mouse model that allows removal of IRF4 from …
IRF4 Activity Is Required in Established Plasma Cells to Regulate …
WebAug 1, 2024 · IRF4 has defined roles in transcriptional regulation and binds to interferon‐stimulated response elements (ISRE). Next, we searched ISRE on the promoter … WebJul 15, 2024 · Key findings: PTTG1 knockdown reinforced the inhibitory effect of IR on the invasive ability of A549 cells and enhanced the antitumour T cell immunity induced by IR … can fleas stick to humans
Frontiers A Comprehensive Pan-Cancer Analysis for Pituitary …
WebApr 1, 2007 · In all PTTG1-EGFP-expressing cells that underwent apparent normal mitosis, PTTG1-EGFP was degraded about 1 min before anaphase onset, consistent with the … WebSep 1, 2006 · IRF4 and IRF8 can function as transcriptional repressors when bound to an ISRE motif but as transcriptional activators when bound to an ETS/ISRE composite DNA … WebIRF4 is one of only 2 genes, along with tyrosinase (TYR), known to affect the skin, eye, hair, and together with the melanocortin 1 receptor (MC1R), freckling. IRF4 independently … can fleas reproduce on humans