WebIn further Mendelian randomization analysis, the predicted OR for 10 pg/mL increment in IL-10 levels was 1.14 (95% CI: 1.01–16.99) in HEACs. Our findings provided strong evidence for a critical role of genetically elevated circulating IL-10 levels in the development of HEACs, especially in Asian population and for nasopharyngeal cancer ... Web12 Nov 2024 · Recently, a general guideline for ROH analysis using PLINK for medium-density SNP data has just been developed (Meyermans et al., 2024); however, a criterion about a minimum length threshold for ROH remains unsolved. Since our approach allows the detection of homozygous segments affecting a trait, the decision to exclude non …
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Web4 Apr 2024 · The ROH consisted mainly of shorter segments (1-2 Mb), which accounted for approximately 67% of the total ROH. The estimated inbreeding coefficients of the ROH ranged from 0.028 to 0.058 with a ... Web19 Sep 2024 · On the X axis is the polymorphic loci set used for the analysis: 21k set corresponds to default SNP set provided by NGSCheckMate and selected based on allelic frequencies of polymorphic loci in dbSNP in a set of 40 germline WGS profiles from TCGA stomach cancer patients; set 300k consists of 312,458 polymorphic loci selected from … the auto 5
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Web29 Jan 2024 · DOI: 10.1186/s12864-020-6463-x Abstract Background: PLINK is probably the most used program for analyzing SNP genotypes and runs of homozygosity (ROH), both … Web18 Nov 2024 · A significant part of any individual human genome is represented by the runs of homozygosity (ROH). The total length and distribution of such regions are related to the genetic-demographic history of the population and reflect the founder effects and the level of inbreeding and may also be caused by a strong directed selection [1, 2].Contemporary … Web30 Jan 2024 · ROH studies have predominantly exploited SNP array data, but are gradually moving to whole genome sequence (WGS) data as it becomes available. WGS data, … the greatest common divisor of 198 and 36