WebWe discovered two ubiquitination sites in the cytoplasmic part of RTN4B, where each site contained two serine residues that are targeted by SdeA for ubiquitination ( Extended … WebOct 14, 2012 · The M2 isoform of pyruvate kinase (PKM2) is a key glycolytic enzyme that is overexpressed in cancer cells; here, serine is shown to bind to and directly activate …
Non-canonical ubiquitination of the cholesterol-regulated degron …
WebJul 20, 2024 · Ubiquitination is promoted by a cascade of ubiquitinating enzymes and counter-regulated by deubiquitinating enzymes (DUBs). ... however, in rare cases, ubiquitin can also bind to serine, threonine ... WebJan 28, 2024 · A new study by Gan et al (2024) reveals that L. pneumophila reverses this noncanonical ubiquitination via its ubiquitin deamidase effector MvcA to allow precise temporal regulation of host signaling during infection. Ubiquitination is a prevalent post-translational protein modification in eukaryotic cells and plays key roles in numerous ... far east network tokyo
Radiation induces IRAK1 expression to promote radioresistance …
Webserine (Ser) residues via phosphodiester bonds (ubiqui-tin attachment via arginine through the ribosyl group), mediated by bacterial pathogen-derived effectors (7). Ubiquitin ADP ribosyl Ser phosphodiesters can be hy-drolyzed by the esterase activity of SidJ (8). Second, protein ubiquitination via esterification of Thr and Ser WebNov 5, 2024 · In addition to ubiquitination, deubiquitination of FANCD2 and FANCI appears to be important in the regulation of the FA pathway. There are two possible explanations for this phenomenon. ... M.M.; Meetei, A.R. ATR-dependent phosphoryklation of FANCM at serine 1045 is essential for FANCM functions. Cancer Res. 2013, 73, 4300–4310. … WebAug 30, 2024 · The canonical ubiquitination reaction consists of a covalent attachment of ubiquitin to internal lysine or N-terminal residues of target proteins through a three-step mechanism that typically... corpus type mucosa